CACNA1D and Parkinson disease: This study demonstrated that 4 weeks of treadmill training decreased the Cav1.3 subunits, inhibited NMDA receptors and auto-phosphorylation of CAMKII at Thr 286, decreased intracellular Ca2+ in the striatum, and improved walking asymmetry in the 6-OHDA-induced PD rat models (Chen et al., 2017).