CDH1 and colitis: Other microbial metalloproteases impairing full-length E-cadherin have been documented, including a GelE produced by commensal Enterococcus faecalis strains; GelE was shown to trigger loss of extracellular E-cadherin and barrier breakage, contributing to the development of experimental colitis in E. faecalis mono-associated IL-10−/− mice, irrespective of antigen-specific activation of colitogenic CD4+ T cells (Steck et al., 2011).