CDH1 and periodontitis: In calvarial infection and experimental periodontitis, A. muciniphila attenuated P. gingivalis-induced bone destruction and inflammatory responses; the gut symbiont suppressed pro-inflammatory IL-12 secretion and gingipain generation, whereas it raised anti-inflammatory IL-10, and improved the expression of junctional markers integrin-β1, E-cadherin and ZO-1 (Huck et al., 2020).