CDH1 and atopic eczema: In eczematous dermatitis, soluble stimuli like LPS, proinflammatory cytokines, and TGF-β significantly increase ADAM10-dependent E-cadherin shedding, impairing keratinocyte cohesion and contributing to the disease’s molecular pathology through the activation of MAPK signaling, which regulates sE-cad release (Maretzky et al., 2008).