Specific CDH1 polymorphisms, such as the CDH1 GTC risk haplotype (a 3-SNP haplotype: rs12597188, rs10431923, and rs9935563), which has an estimated allelic frequency of 21%, have been linked to abnormal E-cadherin trafficking and are significantly associated with an increased susceptibility to Crohn’s disease (Muise et al., 2009). The gene discussed is CDH1; the disease is Crohn disease.