In fact, one of the hallmarks of benign prostate hyperplasia, termed “inflammaging” (i.e., chronic slow-progressing inflammation in the aging prostate), was phenotypically enhanced even in E-cadherin deficient mice without complete deletion (CDH1+/- mice), accompanied by increased prostatic macrophage infiltration and bladder overactivity (Pascal et al., 2022). Here, CDH1 is linked to benign prostatic hyperplasia.