CDH1 and leptospirosis: Leptospira interrogans, etiological agent of leptospirosis, one of the most significant zoonoses globally, is known to displace E-cadherin from the membrane and drive cytoskeletal rearrangement and AJ disassembly by hijacking the host cells’ ubiquitinin-proteasomal system (UPS) and/or lysosomal degradation pathways.