In an earlier study, TD curcumin limited endothelial dysfunction and preserved vascular integrity in a rat model of lipopolysaccharide-induced inflammation (40) and its antihematotoxic (41) and acute vasoregulatory (42) effects complement our observations of significant reduction in cold hypersensitivity and improvement in Hb-related parameters in HbSS mice. This evidence concerns the gene GSTM1 and endothelial dysfunction.