GLRA2 and autism spectrum disorder: In addition to the studies documented above for GlyR α2 subunit knockout mice, investigation of a potential role for GlyR α2 dysfunction in human neurological disorders was first prompted after several large-scale sequencing projects documented rare GLRA2 missense variants in isolated cases of autism spectrum disorder (ASD; Pinto et al., 2010; Piton et al., 2011; Iossifov et al., 2014; Pilorge et al., 2016; Supplementary Table S1).