Given that our previous experiments revealed that remote ischemic postconditioning improved renal injury, slowed senescence, and decreased serum IL-6 levels in rabbits with RM-AKI, this study aims to investigate the mechanisms underlying the role of IL-6 in RM-AKI-induced renal cellular senescence by simulating RM-associated renal injury in vitro and administering an IL-6 receptor blocker (Zager and Burkhart, 1997). The gene discussed is IL6; the disease is acute kidney injury.