In vitro experiments shows that Zharp1-211 was highly potent for blocking TNF-induced necroptosis in human colon cancer HT-29 cells and mouse fibroblast L929 cells, and reduced IFN-γ–induced STAT1 activation in mouse intestinal crypt cells by effecting JAK1/STAT1 pathway. Here, STAT1 is linked to colonic neoplasm.