KEAP1 and neoplasm: NRF2, a master regulator of cellular redox homeostasis and xenobiotic detoxification (35), is often associated with elevated NFE2L2/NRF2 expression, oncogenic activity of NRF2, tumor growth, metastasis, and resistance to anticancer treatments, primarily due to Kelch-like ECH-associated protein 1 (KEAP1) mutations (36–38).