In a mouse model of asbestos-induced pulmonary fibrosis, CSF-1 monoclonal antibodies or inhibitor PLX3397 were used to block the CSF-1/CSF-1R signaling pathway to reduce monocyte differentiated alveolar macrophages and the alleviated pulmonary fibrosis was observed (58). This evidence concerns the gene CSF1 and pulmonary fibrosis.