Numerous studies on different plants have been shown to significantly reduce ALI manifestations, such as a decline in neutrophils infiltration and toll-like receptor pathways (TLR4, NF-ĸβ, COX-2) and, consequently, TNF-α, Interleukins (IL-1, -6, -8, -10) and chemokines by reducing oxidative stress in experimental animals (Aboushanab et al., 2021; Liou et al., 2017; Baradaran Rahimi et al., 2019; Shokry et al., 2022; Feng et al., 2019; Tian et al., 2019a; Erdenechimeg et al., 2017; Feng et al., 2024; Tian et al., 2019b; Xing et al., 2019). The gene discussed is TNF; the disease is acute respiratory distress syndrome.