VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′ cap‐mediated oncogenic protein synthesis (by interrupting eIF4E‐Mnk1/2 signaling) and induces apoptosis in prostate cancer cells. This evidence concerns the gene AR and Familial prostate cancer.