Additionally, we reported the major mechanism of action of 433‐3β that promotes proteasomal degradation of AR and Mnk1/2 in PCa cells, thus regulating AR‐driven oncogenic transcription and mRNA 5′ cap‐dependent deregulated protein synthesis mediated by eIF4E‐Mnk1/2 [25, 34]. Here, EIF4E is linked to posterior cortical atrophy.