Using comparative proteomics, we demonstrate that 433‐3β modulated the expression of several upstream regulator proteins thereby exerting its ancillary effects in inhibiting PCa and PCa stem cells as demonstrated by diminished Notch4 signaling, ILF3 and CDK19 required for stemness and potentially PCa recurrence as we previously reported using transcriptome analysis [25, 35]. Here, CDK19 is linked to posterior cortical atrophy.