Interestingly, 28 major oncoproteins, including CDK2 implicated in PCa progression [59] and STAT3 critical for PCa cell proliferation and metastasis [60, 61], are downregulated by 433‐3β while 21 tumor suppressor proteins, especially TPM1, a known PCa suppressor [62] upregulated compared with the control (Fig. 3D,E). Here, CDK2 is linked to posterior cortical atrophy.