However, TGF‐β depletion does not affect bladder development in female mice due to the modulation of estrogens and androgens.[107] In PCa, ADT recruits B cell infiltration by CXCL13+ myofibroblasts, promoting the development of CRPC.[108] Mechanistically, hypoxia‐induced activation of HIF1α enhances the generation of CXCL13+ myofibroblasts by upregulating the TGF‐β pathway. Here, HIF1A is linked to posterior cortical atrophy.