AR and posterior cortical atrophy: YAP is a key gene in the Hippo pathway that is activated by the AR.[79] Polymorphonuclear monocytic myeloid‐derived suppressor cells (MDSCs) have been identified as the primary infiltrating immune cells in PCa progression within the TME.[80] Mechanistically, CXCL5 overexpression via the Hippo/YAP pathway activates CXCR2, thereby attracting polymorphonuclear MDSCs into the TME, which contributes to PCa progression.