IRF1 and cancer: In BC cells, FOXA1 depletion increased PD‐L1 expression, as well as STAT2 and ASG15, by upregulating the transcription of IRF1 in an IFN‐ɣ‐independent manner.[86] In another BC study, FOXA1 expression was negatively correlated with CD8 T cells and positively associated with M2 cancer‐associated macrophage (CAM) infiltration, as determined by the analysis of clinical samples and immunotherapy outcomes.[87] Thus, FOXA1 expression contributes to the establishment of an immunosuppressive TME in both PCa and BC.