CTLA4 and posterior cortical atrophy: Consequently, prostate epithelial cells undergoing ADT secrete IL8 (in humans) or CXCL15 (in mice) to activate the CXCR2 pathway, leading to the recruitment of polymorphonuclear MDSCs into the TME.[44a] The combination of anti‐IL8 or anti‐CXCR2 with anti‐CTLA‐4 and ADT significantly enhanced PCa control by elevating the antitumor function of CD8+ T cells.