Recently, membrane sex hormone receptors have been shown to influence the occurrence and progression of urological diseases.[63] Mechanistically, the interaction between dehydroepiandrosterone and ADGRG2, an adhesion G protein‐coupled receptor, is linked to male fertility.[64] Similarly, GPR126, another adhesion G protein‐coupled receptor, is activated by progesterone to promote breast cancer progression via the GI pathway, both in vitro and in vivo.[65] These findings suggest the need to further investigate the role of AR in the immune modulation of BC. This evidence concerns the gene ADGRG2 and breast cancer.