E2F1 and posterior cortical atrophy: The interaction between the AR and BMI1 notably affects PCa progression and resistance to ADT.[66] BMI1+ luminal progenitor cells facilitate the regeneration and self‐renewal of the prostate in mice by activating the IKKα/E2F1/BMI1 axis, which involves the infiltration of B cells.[67] In PTEN‐deficient mice, BMI1+ luminal progenitor cells have been identified as the origin of tumors.