CD8A and breast cancer: AR and ADT affected the immune factors and cells to control PCa prognosis.[44, 46] In BC, the reduced expression of TCF7 and TCF1 in CD8+ T cells mediated by AR may lead to T cell exhaustion, creating an immunosuppressive TME that diminishes the efficacy of immunotherapy.[44b] This section delineates and compares the roles of the AR and its regulatory network in PCa and BC, particularly from the perspective of embryonic development.