CD8A and breast cancer: In C3H/HeN mouse models, AR overexpression in BC cells significantly increases the efficacy of anti‐PD‐L1 therapy by promoting CD8+ T cell infiltration, although AR overexpression alone does not affect CD8+ T cell infiltration.[4] Further results indicated that AR overexpression in BC cells cocultured with CD8+ T cells could significantly improve the antitumor function of CD8+ T cells, thus enhancing the efficiency of immunotherapy.[4] These studies highlighted the diverse effects of AR expression in different cell types.