AR and ADT affected the immune factors and cells to control PCa prognosis.[44, 46] In BC, the reduced expression of TCF7 and TCF1 in CD8+ T cells mediated by AR may lead to T cell exhaustion, creating an immunosuppressive TME that diminishes the efficacy of immunotherapy.[44b] This section delineates and compares the roles of the AR and its regulatory network in PCa and BC, particularly from the perspective of embryonic development. This evidence concerns the gene AR and breast cancer.