Elevated levels of these PSA‐expressing exosomes were observed in the blood of PCa patients but not in those with benign prostatic hypertrophy (BPH) or HDs, revealing potential of exosomal PSA as a diagnostic biomarker for PCa.[66] Similarly, high levels of exosomal CD147 were detected in CRC patients, with its expression decreasing after surgery.[67]. This evidence concerns the gene BSG and benign prostatic hyperplasia.