On the contrary, key signalingpathways such as PI3K/AKT/mTOR and Wnt tend to hyperactivate in GBMcases and worsen prognosis by aiding cancer cell proliferation.69 Likewise, discriminators identified throughloading plots can be verified by MSI and serve as a starting pointfor biomarker research, concluding that REIMS-derived informationwith MSI techniques can improve image analysis precision. Here, MTOR is linked to cancer.