In silico analyses reveal that Rutin, Myricetin 3-rhamnoside, and Kaempferol 3-(2′′-rhamnosylrutinoside) from papaya leaf extracts bind to NS1’s key residue ASN130, potentially disrupting NS1-TLR4 interaction and alleviating thrombocytopenia [121]. Here, TLR4 is linked to Thrombocytopenia.