In HS pathogenesis, the rupture of hair epidermal cysts releases endogenous DAMPs such as high-molecular-weight cornified keratin into the dermis [119], which has been shown to activate the NLRP3 inflammasome [120,121], suggesting that DAMPs and pyroptosis may play a role in exacerbating inflammation in HS. The gene discussed is NLRP3; the disease is histiocytic sarcoma.