Another study showed that KDM1A, or lysine-specific histone demethylase 1 (LSD1), a demethylase of the mono- and di-methylated histone H3 lysine 4 (H3K4me1/2) was significantly upregulated while REST was inactivated in human SCLC specimens. Here, KDM1A is linked to small cell lung carcinoma.