Specifically, SIRT1, SIRT2 and SIRT5 have been shown to exhibit potent pro-viral activity by facilitating the replication of a range of viral pathogens [32,33,34,35], while in certain viral infections, SIRT1, SIRT5, and SIRT6 display anti-viral properties [36,37,38]. Here, SIRT1 is linked to viral infectious disease.