JAK2 and Kaposi's sarcoma: The KSHV latency program is the primary driver of the lymphatic reprogramming of KS cells [283,284], which occurs through KSHV-mediated activation of the Janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) and PI3K/Akt/mTOR pathways [285,286].