Similarly, among the genes that were specifically modulated after infection with vPdR-H30K-5U, 7 were upregulated (PPBP, CXCL-8, LAG3, IL-6, ECE1, RAB27B, and EVA1A), and 15 were downregulated (GBP1, TTP, CTLA4, CXCL10, CSF1, TLR9, SLA-DMB, SLA-DQA1, A2M, GAS7, and CD154) (Figure 4b and Figure 5). The gene discussed is TLR9; the disease is infection.