In cells derived from glioblastoma multiforme (GBM) with similar properties to glioma-initiating cells, treatment with THC (0.83 μM), CBD (4.17 μM), and TMZ (100 μM) induced apoptosis, as indicated by the activation of caspase-3 and cleaved PARP. The gene discussed is CASP3; the disease is central nervous system cancer.