CASP3 and small cell lung carcinoma: In lung cancer stem cells and adherent lung cancer cells (A549, H1299, and SCLC H69), CBD (10 μM) activated effector caspases (caspase-3 and caspase-7), increased the expression of pro-apoptotic proteins, elevated ROS levels by 2.5-fold in A549 and H1299 cells (p < 0.0001 and p < 0.05), and caused a significant 60% loss of mitochondrial membrane potential in all non-adherent cell lines when compared to untreated cells (p < 0.001 and p < 0.0001) [43].