Similarly, in a small cell lung cancer (SCLC) model, the proto-oncogene c-Myc recruits HDAC3 to the promoter region of the MICA/B gene, negatively regulating the expression of the NK cell activating receptor (NKG2DL) through histone H3K9 deacetylation, which inhibits NK cytotoxicity and mediates immune inhibition [165]. The gene discussed is MICA; the disease is small cell lung carcinoma.