ERVW-1 and HIV-1 infection: Thus, nNAbs with Fc functions can confer protection or alter the course of HIV-1 infection by binding to cell-free virions to accelerate virus clearance, and/or by binding to HIV-1 Env on the surface of infected cells to induce antibody-dependent cell-mediated cytotoxicity (ADCC) and monocycle/macrophage phagocytosis [57,65,66,67].