This includes various models, such as urokinase-type plasminogen activator/severe combined immunodeficiency (uPA/Scid) transgenic mice [170], FAH−/−RAG2−/−IL2RG−/− (FRG) knockout mice [171,172], herpes simplex virus 1 (HSV1) thymidine kinase (TK) -NOG (Nod/Scid/IL2rg−/−) mice [173,174], and alpha-1-antitrypsin mutant Z protein (PiZ) transgenic NSG mice (NSG-PiZ mice) [175,176]. Here, PLAU is linked to severe combined immunodeficiency.