Pro-angiogenic factors such as vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), fibroblast growth factor 2 (FGF-2), chemokines, and angiopoietins are actively and simultaneously released in the tumor microenvironment and mediate the rapid expansion of the endothelial cells [2,4]. The gene discussed is FGF2; the disease is neoplasm.