In this approach, Park et al. (2021) revealed that docetaxel/doxycycline-loaded FRβ-targeted pH-sensitive L against tumor-associated macrophages and non-small-cell lung cancer showed a synergistic inhibitory effect on tumor growth and suppressing the activity of calpain-2 overexpressed in non-small-cell lung cancer [42]. The gene discussed is CAPN2; the disease is non-small cell lung carcinoma.