Then, by comparing the content of hydroxyproline (HYP) and the content of reactive oxygen species (ROS), the expression of fibrosis-related factors such as TGF-β1, CTGF, IL-6, IL-17, Fn, α-SAM, and Collagen in BLM-induced Beas-2b cells (Human Bronchial Epithelial Cells) and the BLM-induced PF mouse model, we verified that siTGFβ1-LNPs can curtail the advancement of PF [31]. The gene discussed is IL6; the disease is pemphigus foliaceus.