Cardarine, also known by the name of GW501516 (2-[2-methyl-4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methylsulfanyl]phenoxy]acetic acid), is a peroxisome proliferator-activated receptor delta (PPAR-δ) agonist [1] developed in the 1990s as a compound with potential use in cardiovascular and metabolic disorder treatment. Here, PPARD is linked to metabolic disease.