Gingipains load in the brain was correlated with AD diagnosis and pathology (tau and ubiquitin)RgpB gingipain colocalised with neurones, astrocytes, tau tangles, and intracellular Aβ in AD hippocampusPg DNA and Kgp gingipain were identified in the AD cerebral cortex. This evidence concerns the gene MAPT and Alzheimer disease.