TP53 and breast cancer: Some of the synthesized analogs were considered promising antiproliferative agents against breast cancer cell lines, among which compound 123 with R1 = 5-Cl, R2 = Me (IC50 = 0.88 ± 0.08, 0.67 ± 0.06, 4.63 ± 0.38, 6.27 ± 0.49, 3.56 ± 0.47, 6.59 ± 0.81, 5.61 ± 0.36 μM against MCF7, ZR-75-1 “wild-type p53”, BT-474 “mutated-type p53”, HCC1937, MDA-MB-231, MDA-MB-435, and SKBR-3, respectively) showed bio-properties against MDM2 protein (Ki = 0.53 ± 0.03 μM) (Supplementary Figure S23).