EGF and neoplasm: Intravascular macrophages attract tumor cells by producing epidermal growth factor (EGF) and release vascular endothelial growth factor (VEGF) to encourage EC proliferation, leading to the disruption of junctions between ECs, resulting in increased vascular permeability, which facilitates the entry of BCCs into the circulatory system from the paracellular pathway across the vascular endothelium [8].