One study aimed to synthesize and preclinically evaluate a targeted nanosystem for chemo-radiotherapy in colorectal cancer, using RGF encapsulated in Poly(D,L-lactic-co-glycolic acid) (PLGA) nanoparticles coated with a CXCR4 ligand (CXCR4L) and 177Lu as a therapeutic β-emitter. This evidence concerns the gene CXCR4 and colorectal cancer.