RAC2 and prion disease: We compare down/up-regulated proteins from C− versus 5RINM (Figure S7B) with altered proteins related to chemical carcinogenesis, reactive oxygen species (e.g., down-regulated P48962/Slc25a4, P51881/Slc25a5, Q9CQQ7/Atp5f1, or P12787/Cox5a), and prion disease (e.g., down-regulated Q05144/Rac2).