Down regulation of Ing1, a transcriptional activation protein that participates in cellular proliferation, apoptosis, and cellular senesce, and whose upregulation inhibit cell growth and metastasis, of which isoform 1 may function as an oncoprotein, and isoform 2 acts as a negative growth regulator acting as a tumor suppressor [28,29], and is a reader of histone modification marks, promoting the deacetylation of the rRNA transcription factor (UBF) and inhibiting its activity through interaction with mTOR, which regulates the translation of mRNAs [30]. The gene discussed is MTOR; the disease is neoplasm.