Another form of regulated cell death that is initiated by disturbances of extracellular or intracellular homeostasis is the necroptosis, which triggers a specific necrotic cell death pathway involving activation of RIPK3 and MLKL via ZBP1, with an important role in tumorigenesis that implies the potential of targeting necroptosis as a cancer therapy. The gene discussed is ZBP1; the disease is cancer.