PYGM and neoplasm: For glycogen catabolism, down regulation of Pygm protein plays a central role for cellular maintenance and organismal glucose homeostasis, an allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, and the phosphorolytic cleavage of glycogen to produce glucose-1-phosphat; this change is critical to prevent tumors as a treatment-effective option through inhibiting tumor growth in various ways [56].