PPARG and hydrops fetalis: To investigate whether AcAc regulates and attenuates HF through the PPARγ, we used mice for intraperitoneal injection of AcAc (50 mg/kg) for 4 weeks and VA-Lip-shRNA-PPARγ was prepared according to a standard reported method and was administered into CCl4-challenged mice through the tail vein to reduce the expression of PPARγ [27].