STAT3 and colorectal carcinoma: Since actionable increases in PARP1 in CRC are related to the IL-6/Phospho (Tyr705)-Stat3 axis [62], which promotes cell proliferation and survival mediated by cyclin D1 and BCL-xL, respectively [63], such a response could constitute a rheostatic maneuver of CT-26 cells to treatment, possibly related to their greater tolerance, as well as to the shorter duration of the apoptotic stimulus observed in this cell type.