Since actionable increases in PARP1 in CRC are related to the IL-6/Phospho (Tyr705)-Stat3 axis [62], which promotes cell proliferation and survival mediated by cyclin D1 and BCL-xL, respectively [63], such a response could constitute a rheostatic maneuver of CT-26 cells to treatment, possibly related to their greater tolerance, as well as to the shorter duration of the apoptotic stimulus observed in this cell type. This evidence concerns the gene CCND1 and colorectal carcinoma.