Following the establishment of a system for the heterologous production of the major lectin in TBLF (TBL-1) and the resulting production of rTBL-1 [25], Dena-Beltrán et al. [24] observed that exposure to concentrations starting from 61 μg/mL for 24 h was effective in replicating the apoptotic effects of TBLF on SW-480 cells, derived from a locally advanced Dukes’ type B colorectal adenocarcinoma [41] with high expression of wild-type EGFR [42], in terms of proteolytic activation of caspase-3, cleavage of PARP-1, and phosphorylation (Ser139) of histone HA2X [43]. The gene discussed is PARP1; the disease is colorectal adenocarcinoma.