Notably, the presence of hexacosanol (an LCAA) in PCO has been known to induce autophagy through the upregulation of an autophagy-related gene (ATG16L) and anti-microtubule-associated 1A/1B light chain (LC3II) [41] that induce healing events to prevent fatty liver changes [41,53]. The gene discussed is ATG16L1; the disease is fatty liver disease.