This research described the antioxidant (SOD3, CAT, GPX, ATOX1 and COX18) and immunological (IL-1α, IL-1β, IL-6, IL-10, TNFα, NCF4, NFKB, TMED, FCAMR and iNOS) genes in rams that had arthritis and those that did not. This evidence concerns the gene COX18 and arthritic joint disease.