These findings were further confirmed by a decrease in the expression levels of autophagy-related genes (ATG5, ATG7, Beclin1, ATG12, LC3, LAMP1 and LAMP2) and the conversion of LC3-I to LC3-II, and a concomitant increase in expression of p62/SQSTM1 in the placenta of BFII sows, which suggested that dyslipidemia due to maternal obesity may contribute to autophagy injury in pig placenta. The gene discussed is LAMP2; the disease is metabolic syndrome.