Interestingly, in acquired thrombotic thrombocytopenic purpura (TTP), HNP-1 to -3 are reported to bind the central A2 domain of von Willebrand factor (VWF), thus blocking ADAMTS13 binding and providing a novel link between inflammation/infection and the onset of microvascular thrombosis [82,83,84]. The gene discussed is VWF; the disease is thrombotic thrombocytopenic purpura.