Moreover, the intratumoral Methylobacterium was significantly associated with poor prognosis in patients with gastric cancer; the high abundance of Methylobacterium was inversely correlated with the frequency of CD8+ tissue-resident memory T cells in the tumor microenvironment and the TGFβ expression, thus playing a role in gastric carcinogenesis [57]. The gene discussed is CD8A; the disease is gastric cancer.