IL6 and systemic lupus erythematosus: They produce short-chain fatty acids (SCFAs), such as butyric acid and propionic acid, which can inhibit B cell activity by promoting the proliferation of extrathymic Tregs, suppress the expression of LPS-induced inflammatory cytokines (IL-6, IL-12), and preserve the integrity of the intestinal epithelial barrier function in lupus-prone animals [8].