IFNA1 and systemic lupus erythematosus: On the contrary, a resistant starch (RS)-rich diet generating SCFAs has been shown to suppress Lactobacillus reuteri, known for exacerbating TLR7-dependent SLE activity, thus inhibiting IFN pathways and reducing SLE symptoms in transgenic mice reproducing TLR7-pDC-IFN axis [77].