In addition, in our previous study, by comparing the expression profile and structure of differentially expressed lncRNA cis target genes and mRNAs in HepG2 cells overexpressing swine HEV ORF3, it was revealed that ORF3 may affect the interconversion of pentose and glucuronic acid and mediate the formation of obstructive jaundice by affecting bile secretion, which is of great significance for the function and pathogenesis of HEV ORF3 [24]. The gene discussed is ASZ1; the disease is obstructive jaundice.