TNF and cancer: Further analysis of the GO enrichment and KEGG pathways of differentially expressed mRNAs revealed that six pathways with a high correlation of ORF3 were obtained, which were cellular response to unfolded protein (GO:0034620), inflammatory response (GO:0006954), cytokine activity (GO:0005125), TNF signaling pathway (ko04668), influenza A (ko05164), and pathways in cancer (ko05200).