Interestingly, the circulating Active Memory B-cell (Active MB, IgD−/CD21−/CD27+) values measured during the early phase of infection (T0) were significantly higher in the HIV+ patients (median: 43.0%) in comparison with the HIV- patients (median: 18.4%, p = 0.018) or HDs (median: 4.9%) (Figure 2B). The gene discussed is CD27; the disease is infection.