In the last four years, the world has been forced to face an emerging infectious disease, the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pandemic, due to the lack of therapies capable of fighting this infection and the mortality observed, associated with the excessive production of pro-inflammatory cytokines such as interleukins, interferons, and tumor necrosis factor-α (TNF-α) [81]. The gene discussed is TNF; the disease is infectious disease.