One other interesting difference between type IA strains (including the acne-associated SLST classes A, C, and F) and type IB/II strains (comprising the healthy skin-associated SLST classes H and K) concerns the hyaluronic acid lyase (HYL), which is involved in the degradation of hyaluronic acid (HA), a major component of the extracellular matrix in the dermis and epidermis. The gene discussed is MATK; the disease is acne.