Additionally, CD8+ T cells exhibit exhaustion in active cutaneous Leishmaniasis, whereas cured patients display a more robust multifunctional CD8+ T cell response and an increase in cells expressing a cytotoxic Th1-like profile (IFN-γ+/granzyme-B+/perforin+) compared to patients with active CL [43]. Here, CD8A is linked to cutaneous leishmaniasis.