In mucosal Leishmaniasis, a higher occurrence of Th1 profile cytokines is observed in the peripheral blood of patients, while in the skin (lesion), there is a greater occurrence of inflammatory cytokines such as IFN, an increase in CD8 cells producing Granzyme A (GrzA), LETs, and a lower expression of IL-10 receptor (IL10R). This evidence concerns the gene CD8A and leishmaniasis.