Following PRR activation, cytokines, chemokines, and growth factors, for example, IL-6, chemokine (C-X-C motif) ligand 8 (CXCL8), monocyte chemotactic protein-1 (MCP-1), granulocyte colony-stimulating factor (G-CSF), and granulocyte-macrophage colony-stimulating factor (GM-CSF), are released to guide the recruitment and sustain leukocyte survival in the infection site [120,121,122,123]. This evidence concerns the gene CSF3 and infection.