Transient receptor potential cation channel subfamily V member 1 (TRPV1)+ neurons release calcitonin gene-related peptide (CGRP) during S. aureus-induced skin infections, which inhibits local neutrophil infiltration, decreases IL-1β and TNFα while enhancing IL-10 levels, aggravating the infection. This evidence concerns the gene TRPV1 and skin infection.