IFNG and infection: Adenovirus 5 was used as a delivery vehicle by Brazilian scientists; these studies showed that prophylactic Ad-ASP2/Ad-TS elicited robust type 1 cytokines (TNFα, IFNγ) producing CD8+ effector T cell response and 100% survival from lethal challenge infection in Balb/c and C57BL/6 mice [59,60].