Other bacterial proteins identified for their roles in enhancing bacterial adhesion and pathogenesis during co-infections include streptolysin O (SLO) and streptolysin S (SLS), both of which are toxins produced by S. pyogenes. These proteins facilitate bacterial dissemination and tissue invasion by disrupting host cell membranes and promoting bacterial survival. The gene discussed is KCNMA1; the disease is coinfection.