ITGAE and neoplasm: Moreover, in cancers, TCRαβ+CD8αβ+ T-IELs can eliminate tumor cells expressing NKG2D ligands, such as MICA and ULBP, through FasL-mediated cytotoxicity [154], with the CD103/E-cadherin interaction facilitating contact-dependent killing [155], thereby contributing to the control of tumor progression and invasion.