NFE2L2 and myocardial infarction: Meanwhile, the NAC co-treated group significantly upregulates the Nrf2/HO-1 pathway compared to the 5-FU group, supported by the findings of Khanna et al. [53], which reported the enhanced effect of NAC on the Nrf2 pathway in cigarette-induced myocardial infarction, reducing cardiac oxidative stress.